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IONIS -HTTRx works through the use of antisense oligonucleotides, brief nucleotide sequences that bind to the huntingtin mRNA and trigger the physique to degrade the RNA , halting the interpretation from mRNA to protein WAVE works in the same approach, with one significant distinction: WAVE is allele -particular, which signifies that it should solely target the mRNA of the mutant huntingtin gene , not the conventional huntingtin gene That is necessary as a result

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